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Typhoid Diagnostics study

Typhoid fever has been a huge problem in Papua New Guinea for approximately 30 years. However, the exact magnitude of the problem remains unknown, largely due to poor diagnosis of the disease. In the highlands a febrile patient is often assumed to have typhoid fever when the fever could be the result of one of a number of infections, including malarial and viral infection. Failure to diagnose typhoid fever can have serious health repercussions for the patient; but over diagnosis has public health repercussions, namely driving antibiotic resistance and wasting money through the unnecessary administration of antibiotics. We are evaluating rapid typhoid diagnostic tests and comparing them to the currently used Widal test.

The study aims to determine the most appropriate method of diagnosis of typhoid fever in the PNG setting. This work is funded through an internal PNGIMR grant. The study commenced in mid 2008. Sample collection has been completed and final laboratory analysis is being conducted. The study was completed in 2011 and is being conducted through the Goroka General Hospital Outpatients and a local urban health clinic. The study is being conducted in collaboration with staff at Goroka General Hospital.


Infection and Immunity



Dr William Pomat
Deputy Director - Science and Unit Head

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